Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D ControlsListeria monocytogenesIntracellular Growth

Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth.

Deciphering how Listeria monocytogenes exploits the host cell machinery to invade mammalian cells is a key issue in understanding the pathogenesis of this food-borne pathogen, which can cause diseases ranging from gastroenteritis to meningitis and abortion. In this study, we show that the lysosomal aspartyl-protease cathepsin-D (Ctsd) is of considerable importance for nonoxidative listericidal ...

Cutting Edge: BASH, A Novel Signaling

Cutting Edge: Vitamin D Regulates Lipid

Vitamin D has long been linked to resistance to tuberculosis , an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces mac-rophage antimicrobial functions against Mycobacte-rium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated...

Cutting Edge: Vitamin D-Mediated Human

Apoptosis of B Cells from CD95/Fas-Mediated Cutting Edge: A Novel Mechanism for Rescue